Gradient lasso for Cox proportional hazards model

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Gradient lasso for Cox proportional hazards model

MOTIVATION There has been an increasing interest in expressing a survival phenotype (e.g. time to cancer recurrence or death) or its distribution in terms of a subset of the expression data of a subset of genes. Due to high dimensionality of gene expression data, however, there is a serious problem of collinearity in fitting a prediction model, e.g. Cox's proportional hazards model. To avoid th...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2009

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btp322